NTUSER.DAT file format: Action could not be completed

Hello Good Day to everyone!
I just want to know what are the other ways to remove Virus in the computer. Apart from Safety mode and Restore Factory Settings. It takes time when I do those actions.
I have a License Norton Antivirus 2009 but whenever a virus will detect in the system it cannot be fully removed from the computer.
To think that this Antivirus is copyright and genuine. Just like the files that shown below that I want to delete after I fully scan the computer;
I says that " The action can't be completed because the file is open another program".
Please help me to fully remove the viruses?
Thanks
