Cloned machine how can reset all to defaults

Hi,
Cloned machine, how can reset all to defaults?
We clone our desktops, but i want to reset all settings after cloning as we face lot of conflicts if restored same. I want steps on how to achieve this.
Thanks for the awesome help.
I asked 5 questions today and got answer for all in minutes. Techyv site Rocks.
Gowri.
