“550 5.7.1 Unable to Relay server error” on MS Outlook

Hello,
I am frequently getting this message
'[email protected]' on 19/01/2011 16:30 Server error: '550 5.7.1 Unable to relay'
When I want to send an mail .
I moved to Outlook from Thunderbird, and this problem with Outlook is disheartening me and makes me want to go back to Thunderbird.
I can't find any solution over the internet. Can you tell what to do in this situation?
Thanks in advance.
