Apps not opening after system restore

My computer is acting real slowly so I did system restore. Now when I open some of the applications installed on my pc, it will say “application unavailable”.
Do I need to install those affected applications again? I hope there is something in the registry that I can just edit to make them working again because reinstallation is very time consuming. Please give any possible solutions to my problem. I really need it right now because I use some of those apps for work. I do not want my boss to get mad at me.
Thank you so much.
