Two HDDs in RAID 0 act as one drive

I was looking online today to try to come up with an answer about RAID and its abilities and drawbacks.
However, one question that I couldn't find an answer to is if you can have two HDDs in RAID 0 (striped), then have one HDD act as a mirror for the other two.
In other words, if two HDDs in RAID 0 act as one drive, then can I add another larger hard drive and set that up with the other HDDs to achieve a complete mirror.
I don't necessarily want to use the larger HDD for data access, but I do want it so that if one of my other drives fails, I always have a mirrored backup to use while I rebuild my RAID 0 configuration.
