Is it safe for Virtual Memory be set to no page file?

I notice the pagefile.sys file is consuming almost 2GB of file size. I know this is not an issue for the newer or latest computer right now, but there are some computers that still using 40GB harddrive or less. I already remove the other software / application that is not being use on a regular basis but still the computer is running low on disk space. The Motherboard is not capable of Sata harddrive.
Is it safe to for the Virtual Memory of the windows to be set to no page file or better not to use the pagefile.sys at all?
