Error when running a Microsoft .Net application

Hi,
I was running an application when this Microsoft .Net error message appeared (see below).
I tried clicking the Continue button but whenever I restart the application the error message popped up again.
Can anyone please help me on what to do with the application?
I am not sure if reinstalling the application will solve the problem.

Microsoft .NET Framework
Unhandled exception has occurred in your application. If you click Continue, the application will ignore this error and attempt to continue. If you click Quit, the application will close immediately.
The system cannot find the file specified.
