Black screen with the NTVDM CPU has encountered an illegal instruction error

Hi People,
I have been trying to deal with this problem on restart a black screen and a pop up message was on my screen.
I've briefly looked up in Google how to handle this, but I'd like a more personalized answer.
Here is the info that was in the message
Thanks.

16 bit MS-OS Subsystem
The NTVDM CPU has encountered an illegal instruction.
CS0f2b IP:0122 OP:ff ff 76 6b 0c Choose ‘close’ to terminate the application.
