Windows not responding problem fix

Hi there!
I am going to tell you about one problem of my computer. After starting my computer then it is very good. But sometimes when I click on the mouse I introduce two problem:
1. Then mouse cursor cannot work perfectly.
2. Browser and start bar hang.
A text has been appear in the top bar: not responding?
As a solution then quickly I pressed Ctrl+Alt+Del. But it is the same and no change. Then must be restart my PC.
Can anyone tell me what is the correct solution?
