Having problems while configuring the email in Lotus notes using BIS

Hi,
I’m having problems while configuring the email in Lotus notes using BIS. I have tried several times combining various password, username, mail id, server’s address etc, but still I’m unable to get through the validation process.
Could it be that there is a problem with Lotus Notes? Can this problem be solved by modifying the Domino side?
Please give your opinion.
