Ninite Not Working After Registry Change in Windows 7

Hi,
I changed the registry with W7T and now Ninite won't work. At first I thought it was a component removal, but this can't be the case because I did a test with no changes to the registry, and it works great.

Error:
An error occurred. The connection with the server was reset [0x80072eff]; ; 221
I don't know which registry change caused the problem, but it has to be one of them.
Possibly down to Internet Explorer?? If I had to guess, I would suggest that it has to be something to do with the system.
Nothing has been tweaked, any ideas?
Any help will greatly be appreciated.
